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Issue 7 (1997) Article 2   Go to page: 1 2 3 4 5 6 7
The Management of Postoperative Pain (Continued)

Table 7: Drug-Analgesic interactions

Drug interactions with local anaesthetics

  • drugs competing for plasma cholinesterases, phenobarbitone, beta-blockers, calcium channel blockers, cimetidine, tricyclic antidepressives and antiarrhythmic agents

Drug interactions with NSAIDs

  • Most relate to the antiplatelet and gastrointestinal effects. Oral anticoagulants, tricyclic antidepressives, phenytoin, beta-blockers, and the ACE inhibitor captopril

Drug interactions with opioids

  • Morphine: tricyclic antidepressives, metoclopramide, H2-blockers. Pethidine/meperidine: H2-blockers, barbiturates, phenothiazines, MAOIs, phenytoin. Methadone: tricyclic antidepressives, diazepam, anticonvulsants.

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